Cytotoxic effect of Aeruginosin-865, capsaicin, and resveratrol on mouse cell lines of different origin

The aim of the study was to compare effects three natural bioactive compounds (and their combinations) on normal vs. tumour-transformed mouse cells. cytotoxic effect Aeruginosin-865 (Aer), capsaicin (Cap), resveratrol (Res) and combinations evaluated hepatocytes (AML) tumour cells derived from livers (Hepa) kidneys (Renca). Various concentrations 25 200 μM tested substances were used. Only Aer + Res combination a low concentration had significant Hepa Renca no AML. Cap all cell lines, but tumour-derived showed higher resistance than A significantly increased cytotoxicity found in compared each substance alone. All types similar sensitivity Res. Because possible hepatotoxic effect, we recommend further investigations into side-effects No described or with can be potentially used anticancer treatment. According results, only recommended for evaluation process new drug development. potential limit utilisation these